In recent years, treatment strategies targeting the unique metabolic characteristics of cancer cells, such as aerobic glycolysis, have gradually received attention. Among them, hunger therapy has shown potential therapeutic value by cutting off the glucose supply to cancer cells. However, existing hunger therapy methods have problems such as poor enzyme stability and poor targeting.
On April 1, 2025, the journal Small reported that researchers modified the surface of MXene using a non chemical modification strategy mediated by bovine serum albumin (BSA) to improve its water dispersibility and stability. Subsequently, the modified MXene was combined with manganese dioxide (MnO2) nanoparticles, folate (FA), and glucose oxidase (GOx) to construct a multifunctional nano delivery system (TMBFG). The system aims to achieve hunger and photothermal dual killing of cancer cells by targeted delivery of GOx to cancer cells, combined with photothermal therapy.
The test results show that under 808nm near-infrared light irradiation, the temperature of TMBFG solution increases with concentration, reaching 49.5 ° C even at low concentrations. At a concentration of 0.8mg/mL, it can reach 57.8 ° C within 3 minutes, which is sufficient to kill cancer cells. The photothermal conversion efficiency of TMBF is 55.37%, demonstrating good photothermal stability and reusability.
The in vitro therapeutic effect showed that TMBFG has significant targeting on HeLa cells with high expression of folate receptor (FR), and its fluorescence intensity is 1.6 times that of A549 cells. The MTT assay showed that TMBFG has low toxicity to normal and cancer cells, and can promote cell proliferation at high concentrations, with good biocompatibility. In a nude mouse tumor model, the tumor volume of the TMBFG+NIR group significantly decreased and body weight increased, indicating that the combination therapy has a significant inhibitory effect on tumor growth and has no negative impact on normal growth in mice.

In this work, MXene was used as a nanocarrier, utilizing its high specific surface area and excellent photothermal conversion efficiency to not only improve the stability and targeted delivery efficiency of GOx, but also enhance the therapeutic effect through its photothermal effect. Meanwhile, the surface modification strategy of MXene effectively addresses its poor water dispersibility and susceptibility to oxidation, making the entire nano delivery system more stable and efficient.
This study provides new ideas for the synergistic treatment of hunger therapy and photothermal therapy for cancer, and has important clinical application potential.

Literature name: Water‐Dispersible MXene Governs Glycolysis for Cancer Synergistic Therapy

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