News

Home News

Surface ligand regulated iron oxide nanoparticles for medical applications

new products

Latest News

June 4,2025.

The 14th Shenzhen International Thermal and Heat Dissipation Materials and Equipment Exhibition (CIME2025)

The 14th Shenzhen International Thermal and Heat Dissipation Materials and Equipment Exhibition (CIME2025) will be held from June 4-6, 2025 at the Shenzhen International Convention and Exhibition Center. The exhibition area is 20000 square meters, wi...

May 29,2025.

Photothermal effect of anti-inflammatory and antioxidant properties Enhanced antibacterial hydrogel promotes infected wound healing

During the healing process of infectious wounds, bacterial infection, persistent oxidative stress, and long-term inflammation are the main obstacles. Developing a multifunctional wound dressing that can effectively eliminate bacteria, reduce oxidativ...

May 29,2025.

Ag2S nanodot based microneedle patch for postoperative melanoma recurrence and infectious trauma treatment

In the surgical treatment of malignant melanoma, incomplete tumor resection and extensive skin defects are the main reasons for high local recurrence rates and uncontrolled wound infections, leading to poor prognosis and prolonged patient recovery ti...

May 29,2025.

Light Stimulated Shuangluo gel for Photothermal Treatment of Cancer

Peptide substances have shown great potential in the field of biomaterials due to their high design flexibility, excellent biocompatibility, and degradability. Peptide based stimuli responsive biomaterials endow them with unique functions in drug del...

April 16,2025.

MXene regulates glycolysis for synergistic treatment of cancer

In recent years, treatment strategies targeting the unique metabolic characteristics of cancer cells, such as aerobic glycolysis, have gradually received attention. Among them, hunger therapy has shown potential therapeutic value by cutting off the g...

April 16,2025.

High air stability MXene biointerface thin film electrode

MXene exhibits excellent ion electron dual conductivity mechanism and has become a promising candidate material for biological interface electrodes. However, the exposed Ti atoms on the MXene layer are prone to oxidation in air, leading to severe deg...

April 16,2025.

Two dimensional tungsten based MXene material for hydrogen production by electrolysis of water

Electrolysis of water to produce hydrogen (HER) is the core technology for obtaining "green hydrogen", but existing precious metal catalysts (such as platinum) are expensive and difficult to apply on a large scale. Scientists are turning their attent...

January 9,2025.

The Chinese government supports the vigorous development of powder metallurgy enterprises

The powder metallurgy industry, as an important component of the new materials field, plays a crucial role in promoting the transformation and upgrading of China's manufacturing industry. Powder metallurgy technology, due to its unique process advant...

November 27,2024.

Rocket microneedle assisted deep drug delivery for combination therapy of melanoma

Melanoma is a highly invasive skin cancer, and its treatment faces challenges such as difficulty in penetrating the skin barrier with drugs and systemic side effects. As a unique transdermal drug delivery method, microneedles have many advantages suc...

November 27,2024.

CREKA Modified Silicone in the Treatment of bladder cancer

Bladder cancer, especially non muscle invasive bladder cancer (NMIBC), is the most common malignant tumor of the urinary system. Although cisplatin based chemotherapy has shown significant clinical efficacy as a first-line treatment, its therapeutic ...

Surface ligand regulated iron oxide nanoparticles for medical applications

September 5,2024.
The clearance kinetics of functional inorganic nanoparticles are generally slow, which may pose potential biosafety issues for in vivo applications. One possible elimination pathway for inorganic nanoparticles is renal clearance, but the effectiveness of renal clearance largely depends on the surface physicochemical properties of the given particles, rather than their size and shape.
On May 13, 2024, the Journal of Nanobiotechnology reported that researchers had designed and successfully utilized three small molecule ligands with bisphosphonate groups but different end groups (i.e. anionic, cationic, and zwitterionic groups) to encapsulate ultra small Fe3O4 nanoparticles, and studied the renal clearance behavior of surface ligand regulated ultra small nanoparticles.
Systematic studies have shown that the ultra small Fe3O4 nanoparticles modified with these surface ligands not only have sufficiently small hydrodynamic dimensions to be cleared by the kidneys, but also exhibit excellent T1/T2 MRI contrast enhancement performance.
Combining bladder MRI and urinary Fe content measured by ICP-OES, researchers found Fe3O4 nanoparticles coated with zwitterionic ligands( Fe3O4@DMSA )It exhibits excellent renal clearance due to reduced absorption by RES. By utilizing the diphosphate anchoring group of hydrophilic ligands, Fe3O4@DMSA Successfully labeled with 99mTc to achieve efficient renal clearance MRI/SPECT dual-mode imaging nanoprobes.
It is worth noting that this nanoprobe has demonstrated satisfactory imaging capabilities in the 4T1 xenograft tumor mouse model. In addition, researchers also conducted safety assessment experiments to evaluate Fe3O4@DMSA The biocompatibility was evaluated in vitro and in vivo.

This study provides a simple and effective strategy for constructing kidney removable nanoparticles that can be used for precise disease diagnosis.


SAT NANO is a best supplier of iron oxide Fe3O4 nanoparticle in China, we can supply 10-20nm, 50nm, 100nm, if you have any enquiry, please feel free to contact us at admin@satnano.com

Leave a message Please click here for inquiry
Provide the right solution according to your needs,offer efficient service,leave a message for the product information and requirements you need,customize now!