During the healing process of infectious wounds, bacterial infection, persistent oxidative stress, and long-term inflammation are the main obstacles. Developing a multifunctional wound dressing that can effectively eliminate bacteria, reduce oxidative stress, alleviate inflammation, and regulate the immune microenvironment has important clinical significance.

On March 8, 2025, the Chemical Engineering Journal reported that researchers have developed a compound containing epigallocatechin gallate (EGCG) and Ag2S@MoS2 The injectable multifunctional hydrogel of nano tablet has excellent anti-inflammatory, antioxidant and synergistically enhanced antibacterial ability, which can promote the healing of infected wounds by regulating the polarization of macrophages.

In this work, researchers grafted EGCG onto sodium alginate oxide (OAlg) through a phenolic condensation reaction to obtain a sodium alginate EGCG complex (OAE), and then Ag2S@MoS2 Nanosheets were introduced into the hydrogel of OAE and carboxymethyl chitosan (CMCS) to form a multifunctional hydrogel with photothermal effect (NSOAEC gel). The NSOAEC gel showed good photothermal activity under near-infrared radiation. The free radical scavenging experiment proved that OAE could effectively scavenge superoxide anion (O2-), ABTS and DPPH free radicals, showing excellent antioxidant performance.

Further in vitro studies showed that NSOAEC gel could effectively alleviate oxidative stress in cells, reduce the expression of inflammatory factors and enhance the expression of anti-inflammatory factors, and promote the polarization of macrophages from M1 to M2. due to Ag2S@MoS2 Nanosheets have excellent photo thermal conversion efficiency, which makes NSOAEC gel show synergistic antibacterial effect under NIR irradiation, and can effectively kill Escherichia coli and Staphylococcus aureus.

In this study, a multifunctional NSOAEC gel was prepared by combining bioactive molecules with the photothermal effect, which synergistically enhanced the antibacterial and immunomodulatory abilities, providing a new therapeutic strategy for the treatment of bacterial infected wounds.

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