The application of various inorganic nanoparticles in the fields of biology and medicine has always been of great concern. However, due to non-specific interactions, nanoparticles can form protein corona in biological media, posing obstacles to the translation of nanomedicine into clinical applications.

On March 12, 2024, ACS Nano reported that researchers used a series of dihydrolipoic acids to study the interaction between gold nanoparticles and serum proteins. Some simple analytical techniques (such as agarose gel electrophoresis, ultraviolet visible absorption spectrum and dynamic light scattering) were used to study the formation of protein corona around spherical AuNPs with different surface coatings.

Research has found that stable AuNPs with small ligands such as DHLA or citric acid promote non-specific adsorption of proteins. In contrast, adding hydrophilic groups (such as PEG blocks or oligomeric groups) to DHLA can fundamentally eliminate non-specific interactions, obtain a uniform dispersion, and maintain the unique pink color of gold colloids. Research has found that encapsulating AuNPs with polyethylene glycol or DHLA with added copolymers can fundamentally prevent the formation of corona, regardless of the charge and size of the ligand.

These findings confirm the importance of surface chemistry in controlling protein crown formation and can guide the design of colloidal nanomaterials that are most suitable for biological applications.

SAT NANO is a best of supplier of gold nanopowder in China, we can offer 20-30nm, 50nm, 100nm with 99.99%, if you have any enquiry, please feel free to contact us at admin@satnano.com