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The effect of surface coating of gold nanoparticles on surrounding protein corona

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July 9,2024.

Self assembling high sensitivity AgNPs based paperboard for detecting pharmaceutical pollutants

Silver nanoparticles are widely used as reagents for enhancing Raman scattering in SERS due to their stability and excellent enhancement properties. On March 29, 2024, Nano Convergence reported an economically efficient, easy to operate, and environm...

July 9,2024.

Arginine modified chitosan composite silver loaded MMT synergistically antibacterial for food preservation

Silver based materials have strong antibacterial properties, but their potential toxicity issues cannot be underestimated. Therefore, it is urgent to construct a safe and non resistant dual antibacterial system. On June 6, 2024, Food Hydroloids repor...

July 9,2024.

One step synthesis of multifunctional intelligent textiles by spraying AgNPs/CNTs solution

The integration of nanotechnology and textile engineering has promoted the development and performance improvement of multifunctional intelligent materials in various application fields. On June 13, 2024, the Chemical Engineering Journal reported tha...

June 25,2024.

The effect of surface coating of gold nanoparticles on surrounding protein corona

The application of various inorganic nanoparticles in the fields of biology and medicine has always been of great concern. However, due to non-specific interactions, nanoparticles can form protein corona in biological media, posing obstacles to the t...

June 25,2024.

Gold nanoparticles exert anti osteoarthritis effects by regulating the

Osteoarthritis (OA) is a common degenerative joint disease that can lead to severe pain, motor dysfunction, and even disability. An increasing number of studies have shown that improving the imbalance of gut microbiota in OA and increasing the conten...

June 25,2024.

Conductive polymer modified gold nanoparticle thin film improves neural electrode interface

Implantable neural microelectrodes are considered as a bridge for information exchange between internal organisms and external devices. The long-term reliability of electrode interface function not only depends on its biocompatibility, but also plays...

May 15,2024.

SAT NANO participates in the 17th International (Guangzhou) Surface Treatment Electroplating and Coating Exhibition

SAT NANO participates in the 17th International (Guangzhou) Surface Treatment Electroplating and Coating Exhibition in 2024 The 17th International (Guangzhou) Surface Treatment Electroplating and Coating Exhibition in 2024 will be held from May 15th ...

April 28,2024.

Notice of May Day Holiday in 2024

Dear valued customers,  We would like to express our gratitude for your ongoing support to our company. We would like to inform you that the May Day holiday in 2024 will be from May 1st to May 5th. During this time, our operations and services w...

April 16,2024.

SAT NANO Showcases Latest Nanopowders at the 135th Canton Fair

SAT NANO is pleased to announce our participation in the upcoming 135th China Import and Export Fair (Canton Fair). As a leading provider of high-quality nanopowders, SAT NANO will be showcasing our latest offerings, including nanopowders of metals, ...

April 8,2024.

Gold powder has recently increased significantly, resulting in a significant increase in costs

Recently, with the continuous increase in international gold prices, the domestic retail price of gold has also been continuously rising. After the jewelry gold price broke through the 700 yuan mark on April 3rd, the topic of "jewelry gold price appr...

The effect of surface coating of gold nanoparticles on surrounding protein corona

June 25,2024.
The application of various inorganic nanoparticles in the fields of biology and medicine has always been of great concern. However, due to non-specific interactions, nanoparticles can form protein corona in biological media, posing obstacles to the translation of nanomedicine into clinical applications.

On March 12, 2024, ACS Nano reported that researchers used a series of dihydrolipoic acids to study the interaction between gold nanoparticles and serum proteins. Some simple analytical techniques (such as agarose gel electrophoresis, ultraviolet visible absorption spectrum and dynamic light scattering) were used to study the formation of protein corona around spherical AuNPs with different surface coatings.

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Research has found that stable AuNPs with small ligands such as DHLA or citric acid promote non-specific adsorption of proteins. In contrast, adding hydrophilic groups (such as PEG blocks or oligomeric groups) to DHLA can fundamentally eliminate non-specific interactions, obtain a uniform dispersion, and maintain the unique pink color of gold colloids. Research has found that encapsulating AuNPs with polyethylene glycol or DHLA with added copolymers can fundamentally prevent the formation of corona, regardless of the charge and size of the ligand.

These findings confirm the importance of surface chemistry in controlling protein crown formation and can guide the design of colloidal nanomaterials that are most suitable for biological applications.

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