CAS 7440-05-3 Pd nanopowder Ultrafine Palladium as catalyst
Size:20-30nm Purity:99.95% CAS No:7440-05-3 ENINEC No.:231-115-6 Appearance:black Powder Shape:spherical
Size:20-30nm Purity:99.95% CAS No:7440-05-3 ENINEC No.:231-115-6 Appearance:black Powder Shape:spherical
We can supply different size products of niobium silicide powder according to client's requirements. Size:1-3um; Purity:99.5%;Shape:granular CAS No:12034-80-9;ENINEC No.:234-812-3
Ni2Si particle,99.5% purity,granular shape,is used for Microelectronic integrated circuit, nickel silicide film,etc. Size:1-10um; CAS No:12059-14-2;ENINEC No.:235-033-1
Melanoma is a highly invasive skin cancer, and its treatment faces challenges such as difficulty in penetrating the skin barrier with drugs and systemic side effects. As a unique transdermal drug delivery method, microneedles have many advantages such as painlessness, easy operation, and high patient compliance. However, the existing microneedle technology has problems such as shallow drug delivery depth and single treatment methods, which limit the application and promotion of this technology. On July 11, 2024, Advanced Functional Materials reported that researchers have utilized a rocket microneedle drug delivery system that can achieve deep drug delivery through a self-propelled mechanism, demonstrating good efficacy in combination therapy for melanoma. The upper layer of the microneedle (MN) system in this work is composed of mesoporous silica nanoparticles with photodynamic activity, characterized by covalent bonding of photosensitizers and loading of trametinib (TRA) into the mesopores. TRA is a targeted small molecule drug that targets melanoma cells with excessive activation of the MEK pathway. The lower layer of the microneedles is composed of enzyme cross-linked HA Tyr hydrogel and collagenase (CLG), which can act as a rocket booster to promote the deep penetration of nanoparticles by remodeling the extracellular matrix (ECM) of tumor tissue. Researchers designed three types of microneedles, and test results showed that PcNP/TRA-HA-Tyr (II)/CLG-MN had the deepest penetration into tumor tissue and the longest retention time in vivo. Photodynamic therapy after administration can significantly inhibit the growth of A375 transplanted tumors in mice. When the "rocket microneedle" penetrates the skin epidermis, the upper and lower layers of MN separate. The lower layer of MN expands under the skin to form hydrogel, which regulates the release of CLG, thus reshaping the compact ECM and promoting the diffusion and distribution of drugs. Meanwhile, the mesoporous silica nanoparticles (PcNP/TRA) in the upper layer of MN penetrate deep into the tumor and are internalized by melanoma cells. On the one hand, TRA targets the over activated MEK pathway in melanoma cells, reducing the phosphorylation level of ERK kinase. On the other hand, Pc Si responds to external infrared light stimulation to generate reactive oxygen species, achieving PDT therapy for melanoma. Ultimately, targeted therapy and PDT therapy work together to efficiently kill tumor cells and inhibit melanoma growth. This study provides a new approach for deep penetration of drugs and combined treatment of melanoma, and offers new ideas for the application of microneedle technology in the treatment of important diseases. From Article:A Multifunctional Rocket-Like Microneedle System with Thrusters for Self-Promoted Deep Drug Penetration and Combination Treatment in Melanoma SAT NANO is a best supplier of mesoporous silicon dioxide nanoparticles in China, we can offer 60-80nm, 100-150...
Read MoreBladder cancer, especially non muscle invasive bladder cancer (NMIBC), is the most common malignant tumor of the urinary system. Although cisplatin based chemotherapy has shown significant clinical efficacy as a first-line treatment, its therapeutic effect is still limited for patients with lymphatic vascular invasion (LVI). The formation of LVI is closely related to platelets, which not only hinder drug delivery but also protect tumor cells from chemotherapy-induced cell death and immune attacks. Therefore, inhibiting platelet function has become a key strategy to prevent LVI formation and enhance cisplatin anti-tumor activity. On August 13, 2024, Nano Letters reported that researchers have designed siliceous bodies modified with CREKA peptides（ CREKA@LPT-MSNC ）Nanodrugs achieve targeted inhibition of LVI formation and significantly improve the chemotherapy effect of bladder cancer. This nanomedicine has a core-shell structure, where tirofiban is preferentially loaded into the CREKA modified liposome shell, while cisplatin is embedded in the mesoporous silica nanoparticle core. Experimental results have shown that, CREKA@LPT-MSNC Nanoparticles not only prolong blood circulation, but also have excellent tumor targeting ability, which helps to increase drug concentration at the tumor site while reducing the side effects of antiplatelet therapy. The anti-tumor effect in vivo shows that, CREKA@LPT-MSNC Effectively inhibited the formation of LVI and increased the permeability of tumor blood vessels, thereby improving the drug delivery efficiency within the tumor, promoting the exposure of tumor cells to cisplatin, and ultimately improving the therapeutic effect of cisplatin. In addition, the nanomedicine also has an effective inhibitory effect on tumor metastasis, demonstrating excellent biosafety and biocompatibility. This study not only provides new ideas and methods for the precise treatment of bladder cancer, but also provides a model for the treatment of other types of tumors. From Article:Targeted Inhibition of Lymphovascular Invasion Formation with CREKA Peptide-Modified Silicasomes to Boost Chemotherapy in Bladder Cancer SAT NANO is a best supplier of mesoporous silica nanoparticle in China, we can supply 60-80nm, 100-150nm. If you have any enquiry, please feel free to contact us at admin@satnano.com
Read MoreThe current research on tumor fibrosis mainly focuses on cancer associated fibroblasts, which may play a dual role in promoting and inhibiting tumors. However, whether tumor cells themselves can undergo fibrosis transformation and inhibit parenchymal cells like pulmonary fibrosis to achieve the goal of inhibiting malignant progression of tumors has received less attention. On August 29, 2024, Advanced Science reported that researchers used mesoporous silica nanoparticles (MSN) loaded with trehalose mycorrhizal ester (TDM) to induce tumor cell fibrosis through the dual effects of TDM induced inflammatory granulomas and MSN induced foreign body granulomas. In this work, researchers prepared novel nanoparticles loaded with MSN and TDM, and utilized the dual induction of fibrosis by MSN and TDM to construct a mouse subcutaneous loaded tumor model. They observed its anti-tumor effect and the possibility of inhibiting tumor malignant progression by inducing tumor cell fibroblast transformation, in order to develop a new anti-tumor strategy. Combining in vitro and in vivo studies, it has been shown that TDM/MSN (TM) can effectively enter solid tumors and induce tumor fibrosis, manifested by collagen internalization and inhibition of proliferation and invasion ability, suggesting a potential role in the treatment of tumor fibrosis. But further research has found that extracellular DNA (ecDNA) mediates resistance to fibrosis induction. In order to comprehensively improve the therapeutic effect, WRN nuclease binds with TM to form a novel nanoparticle (TMW), which can effectively clear ecDNA and promote fibroblast like transformation of tumor cells. Its inhibitory effect on cancer progression has been verified in the PDX model. This study reveals the potential of TDM/MSN-WRN (TMW) to induce fibroblast like transformation and related intracellular collagen deposition in tumor cells, thereby inhibiting malignant progression of tumors. It provides a new paradigm for anti-tumor therapy and offers a new theoretical basis and strategy for designing anti-tumor drugs. SAT NANO is a best supplier of mesoporous silica nanoparticles in China, we can offer 60-80nm, 100-150nm, if you have any enquiry, please feel free to contact us at admin@satnano.com
Read MoreThe 14th China International Nanotechnology Exhibition (Nanotech China®) is just around the corner! This annual event has been the most authoritative, influential, and largest-scale international exhibition in the field of nanotechnology application in China since its first launch in 2010. The conference will be held from October 23rd to 25th, 2024. SAT NANO is excited to be a part of this grand event. This year, the conference will have a specific focus on various fields, including micro-nano manufacturing, third-generation semiconductors, flexible printed electronics, nanoscale imprinting, fiber/gel/imaging materials, optoelectronics/lasers, new displays, analysis and detection, and nanotechnology applications. With over 2400 nanotechnology-related companies participating in the conference, the exhibition space of the conference has increased by approximately 10% and will cover an area of 24,000 square meters. The conference will have one main exhibition area and three special exhibition areas, including 520 standard booths and six special exhibition groups. Some of the most renowned scientists, industry experts, and entrepreneurs from around the world have been invited to participate in the conference. This year, the conference has invited more than 20 domestic and foreign academicians, as well as over 450 experts and scholars from government entities and universities. In addition, there will be over a hundred international speakers invited to the main report and subforum speeches. SAT NANO will showcase its latest and most advanced nanotechnology production technology. The company specializes in producing and selling nano metal powders, oxide powders, carbide powders, alloy powders, and quantum dots. SAT NANO is excited to participate in the conference and share its technological advancements and market insights with the industry. We hope to see you in person at our booth at the 14th China International Nanotechnology Exhibition in Shanghai. Our team is looking forward to discussing the latest developments in the field of nanoscience with you and how SAT NANO can provide unique solutions for your company. If you have any enquiry of nanopowder and mircon powder, please feel free to contact us at admin@satnano.com
Read MoreDear customer: Hello! The National Day is coming soon. According to the national statutory holiday regulations, the SAT NANO holiday notice is as follows: Company holiday period: From October 1st to October 7th, 2024, a total of 7 days. During this period, if we have any enquiry, please send it to our email admin@satnano.com, our sales will reply you as soon as possible. Finally, all SAT NANO employees wish you and your family a happy National Day! SAT NANO is a professional manufacturer and supplier of nano powder. We provide various types of metal powder, alloy powder, carbide powder, etc. Our products cover many fields, such as 3D printing, surface coating, catalysis, electronic packaging, conductive adhesive, etc. We always adhere to the attitude of quality first and customer first, providing customers with high-quality products and services. In the past few years, SAT NANO has become one of the leading enterprises in the nano powder industry. We continue to pursue higher product quality, better customer experience and broader market opportunities. We hope that through our unremitting efforts, we can provide our customers with more high-quality nano powder products and services. Thank you again for your attention and support. Wishing you and your company greater success and glory in your future development! SAT NANO Team
Read MoreThe clearance kinetics of functional inorganic nanoparticles are generally slow, which may pose potential biosafety issues for in vivo applications. One possible elimination pathway for inorganic nanoparticles is renal clearance, but the effectiveness of renal clearance largely depends on the surface physicochemical properties of the given particles, rather than their size and shape. On May 13, 2024, the Journal of Nanobiotechnology reported that researchers had designed and successfully utilized three small molecule ligands with bisphosphonate groups but different end groups (i.e. anionic, cationic, and zwitterionic groups) to encapsulate ultra small Fe3O4 nanoparticles, and studied the renal clearance behavior of surface ligand regulated ultra small nanoparticles. Systematic studies have shown that the ultra small Fe3O4 nanoparticles modified with these surface ligands not only have sufficiently small hydrodynamic dimensions to be cleared by the kidneys, but also exhibit excellent T1/T2 MRI contrast enhancement performance. Combining bladder MRI and urinary Fe content measured by ICP-OES, researchers found Fe3O4 nanoparticles coated with zwitterionic ligands（ Fe3O4@DMSA ）It exhibits excellent renal clearance due to reduced absorption by RES. By utilizing the diphosphate anchoring group of hydrophilic ligands, Fe3O4@DMSA Successfully labeled with 99mTc to achieve efficient renal clearance MRI/SPECT dual-mode imaging nanoprobes. It is worth noting that this nanoprobe has demonstrated satisfactory imaging capabilities in the 4T1 xenograft tumor mouse model. In addition, researchers also conducted safety assessment experiments to evaluate Fe3O4@DMSA The biocompatibility was evaluated in vitro and in vivo. This study provides a simple and effective strategy for constructing kidney removable nanoparticles that can be used for precise disease diagnosis. SAT NANO is a best supplier of iron oxide Fe3O4 nanoparticle in China, we can supply 10-20nm, 50nm, 100nm, if you have any enquiry, please feel free to contact us at admin@satnano.com
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