Accurate imaging of collateral circulation and ischemic penumbra is crucial for the diagnosis and treatment of acute ischemic stroke (AIS). Unfortunately, there is currently a lack of high-sensitivity and high-resolution in vivo imaging technology to meet this requirement.
On July 4, 2024, Small reported that researchers had developed for the first time a contrast-enhanced magnetic sensitive weighted imaging (CE-SWI) technique, which is expected to meet the high-precision imaging needs. This technology utilizes Fe3O4 nanoparticles modified with dextran（ Fe3O4@Dextran NPs can perform high sensitivity and resolution imaging of AIS at 9.4T.
Researchers synthesized it at room temperature using a simple co precipitation method Fe3O4@Dextran Nanoparticles have the advantages of small size (hydrodynamic size of 25.8nm), good solubility, high transverse relaxation (r2) (r2 reaches 51.3mM-1s-1 at 9.4T), and good biocompatibility.
Fe3O4@Dextran Nano particle enhanced SWI can easily highlight cerebral blood vessels under a 9.4TMR scanner, with significantly improved contrast and a resolution of 0.1 millimeters, enabling clear identification of collateral circulation spaces in a rat model of middle cerebral artery occlusion (MCAO).
In addition, Fe3O4@Dextran The SWI enhanced by NPs, through matching analysis with other multimodal magnetic resonance sequences, helps to accurately depict the ischemic core, collateral branches, and ischemic penumbra after AIS.

The study's Fe3O4@Dextran Nanoparticle enhanced SWI provides a highly sensitive and high-resolution imaging tool for personalized feature description and precise treatment of stroke patients.

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